Yale University researchers had previously shown that mesenchymal stem cells harvested from bone marrow helped repair spinal cord injury in rats; however, many of the cells did not reach their target injury site. The study by the Yale team, headed by neuroscientists Jeffery Kocsis and Karen Lankford, shows how properties from stem cells can be carried to the macrophages by intercellular cargo vesicles called exosomes. There, the stem cell-derived exosomes may aid macrophages to repair ruptures in the blood-brain barrier that can wreak havoc with the central nervous system. The report appears on January 5 in the journal PLOS ONE. Reference: “Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord” by Karen L. Lankford, Edgardo J. Arroyo, Katarzyna Nazimek, Krzysztof Bryniarski, Philip W. Askenase and Jeffery D. Kocsis, 2 January 2018, PLOS One.DOI: 10.1371/journal.pone.0190358
